Inshinge ebyiri cyangwa enye za plasma ikungahaye kuri platel mu ivi rya osteoarthritis ntabwo yahinduye biomarkers ya synovial, ahubwo yanateje imbere ivuriro.
Dukurikije ikizamini cy’inzobere mu bijyanye n’inganda, bagereranije inshinge ebyiri na enye zo mu nda zatewe na plasma ikungahaye kuri platine (PRP) ku bijyanye n’imihindagurikire ya cytokine ya synovial hamwe n’ibisubizo by’amavuriro.Abarwayi 125 barwaye ivi osteoarthritis (OA) bahawe inshinge za PRP buri byumweru 6.Mbere ya buri gutera inshinge PRP, ibyifuzo bya synovial fluid byakusanyirijwe hamwe kugirango bige.Abarwayi bagabanyijwemo inshinge ebyiri cyangwa enye zatewe inshinge PRP (amatsinda A na B).Impinduka muri biomarkers ya synovial yagereranijwe nurwego rwibanze mumatsinda yombi, kandi ibyavuye mubuvuzi byasuzumwe kugeza kumwaka umwe.
Abarwayi mirongo icyenda na bane barangije gukusanya amazi ya synovial bashyizwe mu isuzuma rya nyuma, 51 mu itsinda A na 43 mu itsinda B. Nta tandukaniro ryigeze riba hagati y’imyaka, igitsina, igipimo cy’umubiri (BMI), n’icyiciro cya radiyo OA.Ikigereranyo cyo kubara cya platel hamwe na selile yamaraso yera muri PRP byari 430.000 / µL na 200 / µL, cytokine. -4, IL-10, IL-13, na IL-1RA) ntabwo byahindutse, kandi Ibintu byo gukura (TGF-B1, VEGF, PDGF-AA na PDGF-BB) byari ku murongo fatizo kandi hagati y'ibyumweru 6 mu itsinda A n'ibyumweru 18 mu itsinda B.
Ibyavuye mu mavuriro muri ayo matsinda yombi byateye imbere cyane kuva mu byumweru 6, harimo na Visual Analog Scale (VAS), Ibipimo by’umurwayi byavuzwe [PROMs;Iburengerazuba bwa Ontario na McMaster Kaminuza Osteoarthritis (WOMAC) Ironderero na Ifishi ngufi-12 (SF-12)], ingamba zishingiye ku mikorere [PBMs;igihe cyo kubyuka (TUG), ibizamini 5 byo kwicara (5 × SST), hamwe niminota 3 yo kugenda (iminota 3 WT)] OA yerekanye ko nta gihindutse kuri cytokine ya synovial nibintu bikura, ariko kandi yazamuye ibyavuye mubuvuzi kuva mubyumweru 6 kugeza kumwaka 1.
Igihe cyo kohereza: Werurwe-03-2022