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Inshinge ebyiri cyangwa enye za plasma ikungahaye kuri platel mu ivi rya osteoarthritis ntabwo yahinduye biomarkers ya synovial, ahubwo yanatezimbere ivuriro.

Dukurikije ikizamini cy’inzobere mu bijyanye n’inganda, bagereranije inshinge ebyiri na enye zatewe mu nda ya plasma ikungahaye kuri platine (PRP) ku bijyanye n’impinduka za cytokine ya synovine hamwe n’ibisubizo by’amavuriro.Abarwayi 125 barwaye ivi osteoarthritis (OA) bahawe inshinge za PRP buri byumweru 6.Mbere yo gutera inshinge PRP, ibyifuzo bya synovial fluid byakusanyirijwe hamwe kugirango bige.Abarwayi bagabanyijwemo inshuro ebyiri cyangwa enye inshinge za PRP (amatsinda A na B).Impinduka muri biomarkers ya synovial yagereranijwe nurwego rwibanze mumatsinda yombi, kandi ibyavuye mubuvuzi byasuzumwe kugeza kumwaka umwe.Abarwayi mirongo icyenda na bane barangije gukusanya amazi ya synovial bashyizwe mu isuzuma rya nyuma, 51 mu itsinda A na 43 mu itsinda B. Nta tandukaniro ryigeze riba hagati y’imyaka, igitsina, igipimo cy’umubiri (BMI), n’icyiciro cya radiyo OA.Ikigereranyo cyo kubara cya platine hamwe na selile yera yamaraso muri PRP byari 430.000 / µL na 200 / µL. -4, IL-10, IL-13, na IL-1RA) ntabwo byahindutse, kandi Ibintu bikura (TGF-B1, VEGF, PDGF-AA na PDGF-BB) byari kumurongo kandi hagati yibyumweru 6 mumatsinda A nibyumweru 18 mu itsinda B. Ibyavuye mu mavuriro mu matsinda yombi byateye imbere cyane kuva mu byumweru 6, harimo na Visual Analog Scale (VAS), Ibipimo by’abarwayi byatangajwe [PROMs;Iburengerazuba bwa Ontario na McMaster Kaminuza Osteoarthritis (WOMAC) Ironderero na Ifoto ngufi-12 (SF-12)], ingamba zishingiye ku mikorere [PBMs;igihe cyo kubyuka (TUG), ibizamini 5 byo kwicara (5 × SST), hamwe niminota 3 yo kugenda (iminota 3 WT)] OA nta gihindutse kuri cytokine ya synovial nibintu bikura, ariko kandi byanonosoye ibyavuye mubuvuzi kuva ibyumweru 6 kugeza kumwaka.


Igihe cyo kohereza: Werurwe-03-2022