Andorogène alopecia (AGA) ni ubwoko busanzwe bwo guta umusatsi buterwa no kuragwa na hormone, bikarangwa no kunaniza umusatsi wumutwe.Mu myaka 60, 45% by'abagabo na 35% by'abagore bahura n'ikibazo cya AGA.FDA yemeye protocole yo kuvura AGA irimo finasteride yo munwa na minoxidil yibanze.Kugeza ubu, kubera kubura imiti ifatika, PRP yabaye ubundi buryo bushya kandi butanga ubundi buryo bwo kuvura.Umubare munini wibintu bikura muri PRP birashobora guteza imbere kuvugurura umusatsi na platel α Ibintu bitandukanye byikura byasohowe na granules bikora kumasemburo yibiti mumisatsi yumusatsi kandi bigatera imitsi mitsi mishya.Nubwo ingingo nyinshi zabitangaje, nta protocole isanzwe yo gutegura PRP, inzira yubuyobozi no gusuzuma ibisubizo byubuvuzi.Iyi ngingo igamije gusuzuma imikorere ya PRP mu kuvura AGA no gucukumbura uburyo butandukanye buriho.
Uburyo bwibikorwa bya PRP:
PRP ikora nyuma yo guterwa mumutwe kugirango irekure ibintu byinshi byo gukura no guteza imbere umusatsi.Izi ngingo zo gukura zirashobora gukora fibroblast, guteza imbere synthesis ya kolagen, kunoza ururenda rwimyanya ndangagitsina no kugenzura imvugo yibintu bikura.Ibintu bikura (PDGF, TGF- β 、 VEGF, EGF, IGF-1) birashobora guteza imbere ikwirakwizwa ry'uturemangingo no gutandukanya, ingirabuzimafatizo ya chemotactique, gutera imisatsi miremire, kandi bigatera imisatsi angiogenez.Ibindi bintu (serotonine, histamine, dopamine, calcium na adenosine) birashobora kongera ububobere bwa membrane kandi bikagenga umuriro.
Gutegura PRP:
Gahunda zose zo gutegura PRP zikurikiza itegeko rusange, kandi anticoagulants (nka citrate) yongerwa mumaraso yakusanyijwe kugirango wirinde kwandura kwizana no gukora platine.Centrifuge kugirango ikureho uturemangingo twamaraso dutukura hamwe na platine.Byongeye kandi, gahunda nyinshi zihitamo abakora platine ya exogenous (nka trombine na calcium chloride) kugirango bateze imbere byihuse ibintu bikura biva muri platine muburyo butandukanye.Amashanyarazi adakora arashobora kandi gukoreshwa na dermal collagen cyangwa autothrombin.Mubisanzwe, ibintu bikura bikura byihishwa nyuma yiminota 10 nyuma yo gukora, kandi 95% byikintu gikura cyogusohora kirekurwa mugihe cyisaha 1, bikamara icyumweru 1.
Gahunda yo kuvura no kwibanda:
Ubusanzwe PRP yatewe inshinge munsi cyangwa imbere.Kugeza ubu, uburyo bwiza bwo kuvura inshuro nintera ntibyashyizweho.Kwishyira hamwe kwa PRP nikintu cyingenzi kigira ingaruka kumavuriro.Ingingo zirindwi zirimo gushyira imbere ko kwibanda kwa PRP inshuro 2 ~ 6, kandi kwibanda cyane bizabuza angiogenez.Haracyari impaka zo kumenya niba irimo selile yera.
Ibisubizo byubushakashatsi biriho byerekana koPRP irashobora gukoreshwa mukuvura AGA.Birindwi muri icyenda ubushakashatsi bwerekanye ibisubizo byiza.Ingaruka za PRP zasuzumwe muburyo butandukanye: Uburyo bwo gutahura PTG, gupima umusatsi, kubara umusatsi hamwe nubucucike bwimisatsi, igihe cyo gukura kugeza igihe cyo kuruhuka, hamwe nubushakashatsi bwakozwe ku barwayi.Ubushakashatsi bumwe bwerekanye gusa ingaruka ziterambere ryamezi 3 yakurikiranwe nyuma yo kuvurwa PRP, ariko ntikibuze amezi 6 yo gukurikirana.Ubushakashatsi bwakorewe igihe kirekire (amezi 6 kugeza 12) bwagaragaje ko umusatsi wagabanutse, ariko byari bikiri hejuru kurwego rwibanze.Ingaruka zo kuruhande zavuzwe gusa nkububabare bwigihe gito mugutera inshinge.Nta ngaruka mbi zavuzwe.
Basabwe kuvurwa:
Kubera ko PRP itabuza urwego rw'imisemburo ijyanye na AGA, birasabwa ko PRP ikoreshwa nk'imiti ivura AGA.Kubwibyo, abarwayi bagomba gushishikarizwa gukomeza imiti yibanze cyangwa umunwa (nka minoxidil, spironolactone na finasteride).Hashingiwe kuri ubu bushakashatsi bwisubiraho, birasabwa gutegura P-PRP (leukopenia) yibanda ku nshuro 3-6 z'amaraso yose.Gukoresha ibikorwa (calcium chloride cyangwa calcium gluconate) mbere yo kuvura bifasha kurekura ibintu bikura.Birasabwa ko inshinge zo mu nsi zigomba gukorwa kuva igice gifite umusatsi muke, kumisatsi no hejuru, kandi aho gutera inshinge bigomba gutandukana.Igipimo cyo gutera inshinge kigenwa nibikenewe kwa muganga.Inshuro yinshinge yatoranijwe kumasomo yambere yubuvuzi (rimwe mukwezi, inshuro eshatu zose hamwe, amezi atatu), hanyuma rimwe mumezi atatu, inshuro eshatu zose hamwe (ni ukuvuga rimwe muri Kamena, Nzeri na Ukuboza).Birumvikana, nyuma yamasomo yambere yubuvuzi, nibyiza kandi guhindura igihe cyigihe kimwe mumezi atandatu.Muri rusange, abarwayi b'igitsina gabo n'abagore bageze ku musaruro mwiza mu kongera umusatsi, kwiyongera k'umusatsi no kuzamura imibereho nyuma yo gutera PRP kuvura AGA (Ishusho 1 n'ishusho 2).
Umwanzuro:
Isubiramo ryibisubizo byinshi byubushakashatsi byerekana ko PRP itanga ikizere cyo kuvura AGA.Mugihe kimwe, kuvura PRP bisa nkaho ari umutekano kandi ingaruka nke.Nubwo bimeze bityo ariko, haracyari kubura uburyo busanzwe bwo gutegura PRP, kwibanda, gahunda yo gutera inshinge, dosiye, nibindi. Biragoye rero gusuzuma imikorere yubuvuzi bwa PRP.Kugirango turusheho kwiga ingaruka za PRP muguhindura umusatsi muri AGA, hasabwa urugero runini rwikigereranyo cyateganijwe (reba inshuro zatewe inshinge, kwibanda kuri PRP, no kugera kubikurikirana igihe kirekire).
Ibiri muri iyi ngingo byongeye gusubirwamo, kandi ntidutanga ingwate iyo ari yo yose cyangwa yerekana ko ari ukuri, kwiringirwa cyangwa kuzuza ibikubiye muri iyi ngingo, kandi ntabwo dushinzwe ibitekerezo by'iyi ngingo, nyamuneka ubyumve.）
Igihe cyo kohereza: Ukuboza-08-2022