Ubuvuzi bugaragara bwa autologique selile ikoresheje plasma ikungahaye kuri platine (PRP) irashobora kugira uruhare runini muri gahunda zitandukanye zo kuvura imiti mishya.Hano ku isi hose harakenewe ingamba zo gusana ingirabuzimafatizo zo kuvura abarwayi bafite imitsi (MSK) n'indwara z'umugongo, osteoarthritis (OA) n'ibikomere bidakira kandi bikomeretsa.Ubuvuzi bwa PRP bushingiye ku kuba imikurire ya platine (PGF) ishyigikira gukira ibikomere no gusana kaskade (gutwika, gukwirakwizwa no kuvugurura).Umubare utandukanye wa PRP wasuzumwe uhereye kubantu, mubushakashatsi bwa vitro ninyamaswa.Nyamara, ibyifuzo byubushakashatsi bwa vitro ninyamaswa mubisanzwe biganisha ku mavuriro atandukanye, kubera ko bigoye guhindura ibisubizo byubushakashatsi butari ivuriro hamwe nibyifuzo byuburyo bwo kuvura abantu.Mu myaka yashize, hari intambwe imaze guterwa mu gusobanukirwa n’ikoranabuhanga rya PRP n’ibinyabuzima, kandi hashyizweho amabwiriza mashya y’ubushakashatsi n’ibimenyetso bishya.Muri iri suzuma, tuzaganira ku majyambere agezweho mu itegurwa no guhimba PRP, harimo ikinini cya platine, ibikorwa bya leukocyte hamwe n’umubiri wavutse kandi uhuza n'imiterere, 5-hydroxytryptamine (5-HT) n'ingaruka zo kugabanya ububabare.Twongeyeho, twaganiriye ku buryo bwa PRP bujyanye no gutwika na angiogenezi mugihe cyo gusana no kuvugurura.Hanyuma, tuzasuzuma ingaruka zibiyobyabwenge bimwe mubikorwa bya PRP.
Autologous platelet ikungahaye kuri plasma (PRP) nigice cyamazi cyamaraso ya autologique peripheral nyuma yo kuvurwa, kandi kwibumbira hamwe kwa platel birenze hejuru y'ibanze.Ubuvuzi bwa PRP bwakoreshejwe mubimenyetso bitandukanye mumyaka irenga 30, bivamo gushishikazwa cyane nubushobozi bwa PRP autogenous PRP mubuvuzi bushya.Ijambo orthopedic biologique biologiya ryatangijwe vuba kugirango rivure indwara zitwa musculoskeletal (MSK), kandi ryageze ku musaruro utanga umusaruro mubushobozi bwo kuvugurura imbaraga za bioactive PRP selile ivanze.Kugeza ubu, ubuvuzi bwa PRP nuburyo bukwiye bwo kuvura bufite akamaro k’ubuvuzi, kandi ibisubizo by’abarwayi byavuzwe birashimishije.Ariko, kudahuza ibisubizo byabarwayi nubushishozi bushya byateje imbogamizi kubikorwa byo kuvura kwa PRP.Imwe mumpamvu zishobora kuba umubare no guhinduka kwa sisitemu ya PRP na PRP kumasoko.Ibi bikoresho biratandukanye mubijyanye na PRP yo gukusanya hamwe na gahunda yo gutegura, bivamo ibiranga PRP idasanzwe hamwe nibinyabuzima.Byongeye kandi, kutumvikana ku bijyanye na gahunda yo gutegura PRP na raporo yuzuye y’ibinyabuzima bikoreshwa mu mavuriro byatumye ibisubizo bya raporo bidahuye.Harageragejwe cyane kuranga PRP cyangwa ibicuruzwa biva mu maraso muburyo bushya bwo kuvura.Byongeye kandi, ibikomoka kuri platine, nka lysates ya platine yabantu, byasabwe kubijyanye na orthopedic no mubushakashatsi bwa vitro stem.
Kimwe mu bitekerezo byambere kuri PRP cyasohotse mu 2006. Intego nyamukuru yiri suzuma ni imikorere nuburyo bwibikorwa bya platine, ingaruka za PRP kuri buri cyiciro cya casade ikiza, nuruhare rwibanze rwibintu bikura bikomoka kuri platine. mu bimenyetso bitandukanye bya PRP.Mubyiciro byambere byubushakashatsi bwa PRP, inyungu nyamukuru muri PRP cyangwa PRP-gel kwari ukubaho nimirimo yihariye yibintu byinshi bikura (PGF).
Muri iyi nyandiko, tuzaganira cyane ku iterambere rigezweho ry’imiterere itandukanye ya PRP hamwe na platelet selile membrane reseptors hamwe n'ingaruka zabyo ku mikorere yubudahangarwa bw'umubiri.Byongeye kandi, uruhare rw'utugingo ngengabuzima dushobora kubaho mu gikoresho cyo kuvura PRP n'ingaruka zacyo mu buryo bwo kuvugurura ingirabuzima fatizo bizaganirwaho ku buryo burambuye.Byongeye kandi, iterambere rigezweho mu gusobanukirwa imiti y’ibinyabuzima ya PRP, ikinini cya platine, ingaruka zihariye z’uturemangingo tw’amaraso twera, hamwe n’ingaruka ziterwa na PGF hamwe na cytokine ku ngaruka ziterwa nimirire y’ingirabuzimafatizo ya Mesenchymal (MSCs), hazasobanurwa, harimo na PRP yibasira bitandukanye. selile na tissue ibidukikije nyuma yo kwimura ibimenyetso bya selile ningaruka za paracrine.Mu buryo nk'ubwo, tuzaganira ku buryo bwa PRP bujyanye no gutwika na angiogenezi mugihe cyo gusana no kuvugurura.Hanyuma, tuzasuzuma ingaruka zidasanzwe za PRP, ingaruka zibiyobyabwenge bimwe mubikorwa bya PRP, hamwe no guhuza PRP na gahunda yo gusubiza mu buzima busanzwe.
Amahame remezo yubuvuzi bwa plasma ikungahaye kuri plasma
Imyiteguro ya PRP iragenda ikundwa cyane kandi ikoreshwa cyane mubuvuzi butandukanye.Ihame shingiro ryubumenyi bwo kuvura PRP ni uko gutera inshinge za platine yibanze aho byakomeretse bishobora gutangira gusana ingirabuzimafatizo, guhuza ibice bishya bihuza no kongera gutembera kwamaraso mu kurekura ibintu byinshi bikora mubinyabuzima (ibintu bikura, cytokine, lysosomes) na poroteyine ya adhesion ishinzwe gutangiza reaction ya hemostatike.Byongeye kandi, poroteyine zo mu bwoko bwa plasma (urugero: fibrinogen, prothrombine, na fibronectine) ziboneka mu bikoresho bya plasma bikennye (PPPs).Kwibanda kwa PRP birashobora gutuma hyperphysiologique irekura ibintu bikura kugirango itangire gukira ibikomere bidakira kandi byihutishe gusana ibikomere bikabije.Mubyiciro byose byuburyo bwo gusana ibice, ibintu bitandukanye byikura, cytokine hamwe nabashinzwe kugenzura ibikorwa byaho biteza imbere ibikorwa byingenzi byingirabuzimafatizo binyuze muri endocrine, paracrine, autocrine na endocrine.Ibyiza byingenzi bya PRP harimo umutekano wacyo hamwe nubuhanga bwo gutegura ibikoresho byubucuruzi bigezweho, bishobora gukoreshwa mugutegura ibinyabuzima bishobora gukoreshwa cyane.Icyingenzi cyane, ugereranije na corticosteroide isanzwe, PRP nigicuruzwa cyikora nta ngaruka mbi zizwi.Icyakora, nta tegeko risobanutse neza ryerekana imiterere n’ibigize PRP yatewe inshinge, kandi ibigize PRP bifite impinduka nini mu maraso, mu maraso yera (WBC), mu maraso atukura (RBC), no kwibanda kwa PGF.
Ijambo rya PRP no gutondekanya
Mu myaka ibarirwa muri za mirongo, iterambere ryibicuruzwa bya PRP bikoreshwa mugutezimbere gusana no kuvugurura ibintu byabaye urwego rukomeye rwubushakashatsi bwibinyabuzima na siyanse yibiyobyabwenge.Cascade ikiza tissue irimo abantu benshi bitabiriye amahugurwa, harimo platine nibintu bikura hamwe na granules ya cytokine, selile yera, matrike ya fibrin hamwe na cytokine nyinshi.Muri ubu buryo bwa caskade, hazabaho inzira igoye ya coagulation, harimo gukora platelet no gukurikiraho gukurikira hamwe na α- Kurekura ibiri mubice bya platine, kwegeranya fibrinogen (kurekurwa na platine cyangwa kubuntu muri plasma) mumurongo wa fibrin, no gushinga ya platel embolism.
“Universal” PRP yigana intangiriro yo gukira
Ubwa mbere, ijambo "plasma ikungahaye kuri platine (PRP)" ryiswe platelet concentrate ikoreshwa mubuvuzi bwo guterwa amaraso, kandi n'ubu iracyakoreshwa.Mu ikubitiro, ibyo bicuruzwa bya PRP byakoreshwaga gusa nka fibrin tissue yifata, mugihe platine yakoreshwaga gusa kugirango ifashe fibrine polymerisation ikomeye kugirango iteze kashe ya tissue, aho kuba imiti ikiza.Nyuma yibyo, tekinoroji ya PRP yashizweho kugirango yigane itangizwa rya casade ikiza.Nyuma, tekinoroji ya PRP yakusanyirijwe hamwe mubushobozi bwayo bwo kumenyekanisha no kurekura ibintu bikura mubidukikije byaho.Iri shyaka ryo kubyara PGF akenshi rihisha uruhare rukomeye rwibindi bice bikomoka kumaraso.Iri shyaka ryarushijeho gukaza umurego kubera kubura amakuru ya siyansi, imyizerere y'amayobera, inyungu z'ubucuruzi no kutagira ubuziranenge no gushyira mu byiciro.
Ibinyabuzima bya PRP yibanze cyane biragoye nkamaraso ubwayo, kandi birashobora kuba bigoye kuruta imiti gakondo.Ibicuruzwa bya PRP nibinyabuzima bibaho.Ibisubizo byubuvuzi bwa PRP bivana nibiranga imiterere yumubiri wumurwayi, harimo nibindi bintu bitandukanye bigize selile zishobora kubaho murugero rwa PRP hamwe na microen ibidukikije byaho byakira, bishobora kuba mubihe bikaze cyangwa bidakira.
Inshamake yo kwitiranya ijambo PRP hamwe na sisitemu yo gutondekanya ibyiciro
Haraheze imyaka myinshi, abimenyereza, abahanga hamwe namasosiyete bahuye nibibazo byo kutumva kwambere hamwe nubusembwa bwibicuruzwa bya PRP n'amagambo yabo atandukanye.Bamwe mu banditsi basobanuye PRP nka platine-yonyine, mu gihe abandi bagaragaje ko PRP irimo kandi selile zitukura, selile zitandukanye z'amaraso yera, fibrin na proteyine bioactive hamwe no kwiyongera kwinshi.Kubwibyo, ibintu byinshi bitandukanye bya PRP biologiya byinjijwe mubikorwa byubuvuzi.Birababaje kubona mubusanzwe ibitabo bidafite ibisobanuro birambuye byimiterere yibinyabuzima.Kunanirwa gutegurwa kubicuruzwa no gutezimbere gahunda yo gutondekanya ibyiciro byatumye hakoreshwa umubare munini wibicuruzwa bya PRP byasobanuwe namagambo atandukanye.Ntabwo bitangaje kuba impinduka mumyiteguro ya PRP ziganisha kubisubizo byabarwayi bidahuye.
Kingsley yakoresheje bwa mbere ijambo "plasma ikungahaye kuri platel" mu 1954. Nyuma yimyaka myinshi, Ehrenfest n'abandi.Sisitemu yambere yo gutondekanya ishingiye kubintu bitatu byingenzi (platelet, leukocyte nibirimo fibrin) byasabwe, kandi ibicuruzwa byinshi bya PRP byagabanijwemo ibyiciro bine: P-PRP, LR-PRP, fibrine ikungahaye kuri platine (P-PRF) na leucocyte umukire PRF (L-PRF).Ibicuruzwa byateguwe na sisitemu ifunze byimazeyo cyangwa protocole yintoki.Hagati aho, Everts n'abandi.Akamaro ko kuvuga selile yera mu myiteguro ya PRP cyashimangiwe.Basabye kandi gukoresha imvugo ikwiye kugirango bagaragaze verisiyo idakora cyangwa ikora ya PRP itegura na gel ya platel.
Delong n'abandi.yatanze icyifuzo cya PRP cyo gushyira mubyiciro byitwa platine, gukora selile yera yera (PAW) hashingiwe ku mubare wuzuye wa platine, harimo na bine ya platine.Ibindi bipimo birimo gukoresha moteri ya platine no kubaho cyangwa kutagira selile yera (ni ukuvuga neutrophile).Mishra n'abandi.Sisitemu isa nayo irasabwa.Nyuma yimyaka mike, Mautner na bagenzi be basobanuye uburyo bunoze kandi burambuye bwo gushyira mu byiciro (PLRA).Umwanditsi yerekanye ko ari ngombwa gusobanura umubare wuzuye wa platine, ibirimo amaraso yera (ibyiza cyangwa bibi), ijanisha rya neutrophil, RBC (positif cyangwa negative) kandi niba hakoreshwa exogenous.Muri 2016, Magalon n'abandi.Ibyiciro bya DEPA bishingiye ku kigero cyo gutera inshinge za platine, gukora neza, kweza kwa PRP kubona no gukora ibikorwa byashyizwe ahagaragara.Nyuma, Lana na bagenzi be batangije gahunda yo gushyira mu byiciro MARSPILL, bibanda ku maraso ya mononuclear periferique.Vuba aha, komite ishinzwe ubumenyi bwa siyansi yashyigikiye ko hakoreshwa uburyo bwo gushyira mu byiciro umuryango mpuzamahanga w’ubuvuzi bwa Thrombose na Hemostasis, bushingiye ku byifuzo by’ubwumvikane buke kugira ngo harebwe ikoreshwa ry’ibicuruzwa bya platine mu miti y’ubuvuzi bushya, harimo n’ibicuruzwa bya platine byafunzwe kandi byashonze.
Hashingiwe kuri gahunda yo gushyira mu byiciro PRP yatanzwe n’abimenyereza n’abashakashatsi batandukanye, kugerageza kunanirwa kugereranya umusaruro, ibisobanuro na formula ya PRP bizakoreshwa n’abaganga birashobora gufata umwanzuro ukwiye, bikaba bishoboka ko bitazabaho mu myaka mike iri imbere Byongeye kandi , tekinoroji yibicuruzwa bya PRP bikomeje gutera imbere, kandi amakuru yubumenyi yerekana ko hakenewe imyiteguro itandukanye ya PRP kugirango ivure indwara zitandukanye mubihe byihariye.Kubwibyo, turateganya ko ibipimo nibihinduka byibyiza bya PRP bizakomeza kwiyongera mugihe kizaza.
Uburyo bwo gutegura PRP burimo gukorwa
Ukurikije imvugo ya PRP nibisobanuro byibicuruzwa, sisitemu nyinshi zo gutondekanya zirekurwa kubikorwa bitandukanye bya PRP.Kubwamahirwe, nta bwumvikane kuri sisitemu yuzuye yo gutondekanya PRP cyangwa ikindi kintu cyose cyamaraso na autologique.Byiza, sisitemu yo gutondeka igomba kwitondera ibintu bitandukanye biranga PRP, ibisobanuro hamwe nizina rikwiye rijyanye nicyemezo cyo kuvura abarwayi bafite indwara zihariye.Kugeza ubu, imitekerereze ya orthopedic igabanya PRP mu byiciro bitatu: fibrine ikungahaye kuri platine (P-PRF), PRP ikungahaye kuri leucocyte (LR-PRP) na PRP (LP-PRP).Nubwo bisobanutse neza kuruta ibisobanuro rusange byibicuruzwa PRP, ibyiciro bya LR-PRP na LP-PRP biragaragara ko bidafite umwihariko mubigize selile yera.Bitewe nubudahangarwa bwacyo hamwe nuburyo bwo kwirwanaho, selile yamaraso yagize ingaruka cyane kubinyabuzima bwimbere bwindwara zidakira.Kubwibyo, PRP yibinyabuzima irimo selile yihariye yamaraso irashobora guteza imbere cyane kugenzura ubudahangarwa no gusana ingirabuzima fatizo.By'umwihariko, lymphocytes ni nyinshi muri PRP, itanga insuline imeze nkikura kandi igafasha guhindura imyenda.
Monocytes na macrophage bigira uruhare runini mugikorwa cyo kugenzura ubudahangarwa hamwe nuburyo bwo gusana ingirangingo.Akamaro ka neutrophile muri PRP ntigisobanutse.LP-PRP yagenwe nkimyiteguro ya mbere ya PRP nisuzuma rifatika kugirango igere ku bisubizo bifatika bivura OA ihuriweho.Ariko, Lana n'abandi.Ikoreshwa rya LP-PRP mu kuvura ivi OA rirarwanywa, ibyo bikaba byerekana ko uturemangingo twihariye twamaraso twera tugira uruhare runini mugikorwa cyo gutwika mbere yo kuvugurura ingirabuzima fatizo, kuko zirekura molekile ziterwa no gutwika.Basanze guhuza neutrophile hamwe na platine ikora byagize ingaruka nziza kuruta ingaruka mbi zo gusana ingirangingo.Bagaragaje kandi ko plastike ya monocytes ari ingenzi mu mikorere idahwitse no gusana mu gusana ingirangingo.
Raporo ya gahunda yo gutegura PRP mubushakashatsi bwamavuriro ntabwo ihuye cyane.Ubushakashatsi bwinshi bwatangajwe ntabwo bwatanze uburyo bwo gutegura PRP busabwa kugirango gahunda isubirwemo.Nta bwumvikane busobanutse mubimenyetso byo kuvura, biragoye rero kugereranya ibicuruzwa bya PRP nibisubizo bifitanye isano no kuvura.Mu bihe byinshi byavuzwe, ubuvuzi bwa platine bwashyizwe mu ijambo "PRP", ndetse no ku ivuriro rimwe.Kubice bimwe byubuvuzi (nka OA na tendinose), intambwe imaze guterwa mugusobanukirwa impinduka zimyiteguro ya PRP, inzira zo gutanga, imikorere ya platel nibindi bikoresho bya PRP bigira ingaruka kumasanwa no kuvugurura ingirangingo.Icyakora, ubushakashatsi buracyakenewe kugira ngo abantu bumvikane ku magambo ya PRP ajyanye n’ibinyabuzima bya PRP kugira ngo bavure neza kandi neza indwara zimwe na zimwe n'indwara.
Imiterere ya PRP sisitemu yo gutondekanya
Ikoreshwa rya autologique PRP biotherapy ihangayikishijwe nuburyo butandukanye bwimyiteguro ya PRP, kuvuga amazina adahuye hamwe no kutubahiriza amabwiriza ngenderwaho ashingiye ku bimenyetso (ni ukuvuga ko hari uburyo bwinshi bwo kwitegura kubyara amavuriro yo kuvura).Birashobora guhanurwa ko ibirimo PRP byuzuye, ubuziranenge nibinyabuzima biranga PRP nibicuruzwa bifitanye isano biratandukanye cyane, kandi bigira ingaruka kumikorere yibinyabuzima nibisubizo byubuvuzi.Guhitamo ibikoresho byo gutegura PRP bitangiza urufunguzo rwambere ruhinduka.Mubuvuzi bushya bwo kuvura, abimenyereza barashobora gukoresha ibikoresho bibiri bitandukanye byo gutegura PRP.Imyiteguro ikoresha uturemangingo dusanzwe twamaraso, ikora kumaraso yuzuye yegeranijwe ubwayo.Ubu buryo bukoresha uburyo bwa centrifuge burigihe cyangwa tekinoroji yo gutandukanya disiki hamwe nintambwe ikomeye kandi yoroshye ya centrifuge.Ibyinshi muri ibyo bikoresho bikoreshwa mu kubaga.Ubundi buryo ni ugukoresha gravity centrifugal tekinoroji nibikoresho.G-force centrifugation ikoreshwa mugutandukanya urwego rwumuhondo wa ESR nigice cyamaraso kirimo platine na selile yera.Ibi bikoresho byo kwibandaho ni bito kuruta gutandukanya amaraso kandi birashobora gukoreshwa kuruhande rwigitanda.Itandukaniro ģ - Imbaraga nigihe cya centrifugation biganisha ku itandukaniro rikomeye mumusaruro, kwibanda, kweza, kubaho, hamwe na reta ikora ya platine yihariye.Ubwoko bwinshi bwibikoresho byo gutegura PRP byubucuruzi birashobora gukoreshwa mubyiciro byanyuma, bikavamo izindi mpinduka mubicuruzwa.
Kutumvikana ku buryo bwo gutegura no kwemeza PRP bikomeje gutuma habaho ukudahuza imiti ya PRP, kandi hariho itandukaniro rinini mu itegurwa rya PRP, ireme ry’icyitegererezo n’ibisubizo by’amavuriro.Ibikoresho bisanzwe byubucuruzi PRP byagenzuwe kandi byandikwa hakurikijwe ibisobanuro byakozwe n’umushinga nyirizina, bikemura impinduka zitandukanye mubikoresho bya PRP bihari ubu.
Sobanukirwa ibipimo bya platine muri vitro no muri vivo
Ingaruka zo kuvura PRP hamwe nizindi platine yibanda ku gusohora ibintu bitandukanye bigira uruhare mu gusana no kuvugurura.Nyuma yo gukora platine, platine izakora platine trombus, izakora nka matrice idasanzwe yigihe gito kugirango iteze ikwirakwizwa ryimikorere no gutandukana.Kubwibyo, birakwiye ko twibwira ko ibipimo byinshi bya platine bizatuma habaho kwibumbira hamwe kwa bioaktike yibintu.Nyamara, ihuriro riri hagati yimiti nubunini bwa platine hamwe nubunini bwibintu bikura bya bioaktike bikura hamwe nibiyobyabwenge bishobora kutagenzurwa, kuko hariho itandukaniro rikomeye mumibare fatizo ya platine yibanze hagati yabarwayi ku giti cyabo, kandi hariho itandukaniro hagati yuburyo bwo gutegura PRP.Mu buryo nk'ubwo, ibintu byinshi byo gukura kwa platine bigira uruhare muburyo bwo gusana ingirangingo biboneka muri plasma igice cya PRP (urugero, ibintu bikura umwijima hamwe na insuline imeze nka 1).Kubwibyo, ibipimo byinshi bya platine ntabwo bizahindura ubushobozi bwo gusana ibyo bintu bikura.
Muri vitro PRP ubushakashatsi burazwi cyane kuko ibipimo bitandukanye murubwo bushakashatsi birashobora kugenzurwa neza kandi ibisubizo birashobora kuboneka vuba.Ubushakashatsi bwinshi bwerekanye ko selile zisubiza PRP muburyo butandukanye.Nguyen na Pham berekanye ko kwibanda cyane kwa GF bitari ngombwa byanze bikunze inzira yo gukangura ingirabuzimafatizo, bishobora kutabyara inyungu.Bamwe mubushakashatsi bwa vitro berekanye ko kwibanda kwa PGF bishobora kugira ingaruka mbi.Impamvu imwe irashobora kuba umubare ntarengwa wa selile membrane reseptors.Kubwibyo, iyo urwego rwa PGF rumaze kuba rwinshi ugereranije niyakirwa ryaboneka, bizagira ingaruka mbi kumikorere ya selile.
Akamaro k'amakuru yibanze kuri platelet muri vitro
Nubwo mubushakashatsi bwa vitro bufite ibyiza byinshi, bifite kandi ibibi.Muri vitro, kubera imikoranire ikomeje hagati yubwoko butandukanye bwingirabuzimafatizo mu ngingo iyo ari yo yose bitewe n'imiterere ya tissue hamwe na selile selile, biragoye kwigana muri vitro mubice bibiri byumuco umwe.Ubucucike bw'utugingo bushobora kugira ingaruka ku kimenyetso cy'utugari ubusanzwe buri munsi ya 1% yimiterere yinyama.Ibice bibiri byumuco wibiryo birinda ingirabuzimafatizo guhura na matrise idasanzwe (ECM).Byongeye kandi, tekinoroji yumuco isanzwe izaganisha ku kwegeranya imyanda ya selile no kurya intungamubiri zihoraho.Kubwibyo, mumico ya vitro itandukanye nuburyo bugenda buhinduka, itangwa rya ogisijeni ya tissue cyangwa guhanahana amakuru mu buryo butunguranye, kandi ibisubizo bivuguruzanya byashyizwe ahagaragara, ugereranije ingaruka z’amavuriro ya PRP n’ubushakashatsi bwakozwe na vitro bw’ingirabuzimafatizo, ubwoko bwa tissue na platine. kwibanda.Graziani n'abandi.Byagaragaye ko muri vitro, ingaruka zikomeye ku ikwirakwizwa rya osteoblasts na fibroblast zagerwaho ku gipimo cya PRP platelet cyikubye inshuro 2,5 hejuru y’agaciro fatizo.Ibinyuranye, amakuru y’amavuriro yatanzwe na Parike na bagenzi be yerekanaga ko nyuma yo guhuza umugongo, urwego rwa PRP rwa platel rugomba kongerwa inshuro zirenga 5 ugereranije n’ibanze kugira ngo rutange ibisubizo byiza.Ibisubizo nkibi bivuguruzanya byavuzwe kandi hagati yamakuru yo gukwirakwiza tendon muri vitro nibisubizo byubuvuzi.
Ibiri muri iyi ngingo byongeye gusubirwamo, kandi ntidutanga ingwate iyo ari yo yose cyangwa yerekana ko ari ukuri, kwiringirwa cyangwa kuzuza ibikubiye muri iyi ngingo, kandi ntabwo dushinzwe ibitekerezo by'iyi ngingo, nyamuneka ubyumve.）
Igihe cyo kohereza: Werurwe-01-2023