Nigute PRP ikora?

PRP ikora itesha agaciro alpha granules ivuye muri platine, ikubiyemo ibintu byinshi byo gukura.Gusohora gukomeye kwibi bintu bikura bitangizwa nuburyo bwo gutembera kw'amaraso bigatangira mu minota 10 ya coagulation.Kurenga 95% byibintu byakuze byabanje gusohora bisohoka mugihe cyisaha 1.Kubwibyo, PRP igomba gutegurwa muburyo bwa anticoagulant kandi igomba gukoreshwa mubukorikori, gukubita, cyangwa ibikomere muminota 10 uhereye igihe utangiye.Ubushakashatsi budakoresha anticoagulée yamaraso yose ntabwo ari ubushakashatsi bwa PRP kandi burayobya.

Nkuko platine ikorwa nuburyo bwo kwambara, ibintu bikura biva mu ngirabuzimafatizo binyuze muri selile.Muri ubu buryo, uduce duto twa alfa duhuza na selile ya selile, kandi ibintu bikura bya poroteyine byuzuza imiterere ya bioaktike wongeyeho iminyururu ya histone na karubone ya hydroxyde.Kubwibyo, platine yangiritse cyangwa idakozwe nubuvuzi bwa PRP ntibisohora ibintu bikura bikura kandi bishobora kuvamo ibisubizo bitatengushye.Ibintu bikura byihishwa bihita bihita bijya hejuru yinyuma ya selile ya graft, flap, cyangwa igikomere hakoreshejwe reseptor ya transembrane.

Ubushakashatsi bwerekanye ko abantu bakuze ba mesenchymal stem selile, osteoblasts, fibroblast, selile endothelia selile, na epidermal selile bagaragaza ibyakiriwe na selile kubintu bikura muri PRP.Iyakirwa rya transembrane naryo ritera gukora poroteyine zo mu bwoko bwa endogenous zerekana ibimenyetso biganisha ku mvugo (gufungura) ya selile isanzwe ya selile, nko gukwirakwiza selile, gukora matrix, kwibumbira muri osteoid, synthesis ya kolagen, nibindi.

Akamaro k'ubwo bumenyi nuko ibintu bikura bya PRP bitigera byinjira muri selile cyangwa nucleus, ntabwo ari mutagenic, byihutisha gusa gukangura gukira bisanzwe.Kubwibyo, PRP nta bushobozi ifite bwo gutera ibibyimba.

Nyuma yo gutangira kwambere kwiterambere rya PRP bifitanye isano no gukura, platine ikomatanya kandi igasohora ibintu byiyongera muminsi 7 isigaye mubuzima bwabo.Iyo platine imaze kugabanuka no gupfa, macrophage igera mukarere ikoresheje imiyoboro y'amaraso iterwa na platine ikura imbere kugira ngo ifate umwanya wo kugenzura ibikomere mu guhisha bimwe mubintu bimwe bikura kimwe nibindi.Niyo mpamvu, umubare wa platine uri mu gihimba, igikomere, cyangwa amaraso yometse kuri flap bigena uburyo igikomere gikira vuba.PRP yongeyeho gusa iyo mibare.

Amashanyarazi angahe arahagije?

Ubushakashatsi bwerekanye ko ikwirakwizwa no gutandukanya MSCS ikuze bifitanye isano itaziguye no kwibanda kwa platine.Berekanye umurongo-wo gusubiza umurongo, werekanye ko igisubizo gihagije cya selile yibitekerezo bya platine byatangiye bwa mbere mugihe inshuro enye kugeza kuri eshanu zibarwa zibanze.Ubushakashatsi busa nabwo bwerekanye ko kwiyongera kwa platine byongera ubwiyongere bwa fibroblast nubwoko bwa I kolagen, kandi ko igisubizo kinini cyaterwaga na PH, hamwe nigisubizo cyiza kiboneka kurwego rwa pH nyinshi.

Ubu bushakashatsi ntibwerekana gusa ko hakenewe ibikoresho byibanda kuri platine ihagije, ahubwo binasobanura ibyagezweho mu kuvugurura amagufwa hamwe n’ibisubizo byoroshye byoroheje bifitanye isano na PRP.

Kubera ko abantu benshi bafite ibibanza fatizo bibarirwa kuri 200.000 ± 75.000 kuri μl, umubyimba wa PRP wa miriyoni 1 kuri μl upimye muri alikoti isanzwe ya ml-6 wabaye igipimo cya "kuvura PRP."Icy'ingenzi, ubushakashatsi bwerekanye ko uku kwibanda kwa platel kugerwaho mugihe urwego rwo kuvura rugeze, bityo bikarekura ibintu bikura.

Ibiri muri iyi ngingo byongeye gusubirwamo, kandi ntidutanga ingwate iyo ari yo yose cyangwa yerekana ko ari ukuri, kwiringirwa cyangwa kuzuza ibikubiye muri iyi ngingo, kandi ntabwo dushinzwe ibitekerezo by'iyi ngingo, nyamuneka ubyumve.）