Platelet ikungahaye kuri plasma (PRP)
PRP yakwegereye abantu kuko ikubiyemo ibintu bitandukanye byo gukura, kandi ikoreshwa cyane mububiko bwa maxillofacial, orthopedie, kubaga plastique, amaso yubuvuzi nizindi nzego.Muri 2006, Uebel n'abandi.yabanje kugerageza kwihitiramo ibice byatewe na PRP hanyuma urebe ko ugereranije n’ahantu hagenzurwa umutwe, agace katewe na PRP kavuwe umusatsi karokotse ibice 18.7 / cm2, mugihe itsinda ryigenzura ryarokotse ibice 16.4./ cm2, ubucucike bwiyongereyeho 15.1%.Kubwibyo, biravugwa ko ibintu bikura byasohowe na platine bishobora gukora kumasemburo yumusemburo wimisatsi yumusatsi, bigatera itandukaniro ryingirabuzimafatizo kandi bigateza imbere imiyoboro mishya y'amaraso.
Muri 2011, Takikawa n'abandi.washyizemo saline isanzwe, PRP, heparin-protamine microparticles ifatanije na PRP (PRP & D / P MP) mugutera inshinge zo munsi yuburwayi bwa AGA kugirango bashireho igenzura.Ibisubizo byerekanye ko agace kambukiranya umusatsi mu itsinda rya PRP hamwe nitsinda ry’abadepite ba PRP & D / P ryiyongereye ku buryo bugaragara, fibre ya kolagen na fibroblast mu misatsi y’imisatsi yagwiriye munsi ya microscope, n’imiyoboro yamaraso ikikije imisatsi yariyongereye.
PRP ikungahaye kubintu bikura bikomoka kuri platel.Izi poroteyine zingenzi zigenga kwimuka kwimitsi, kwizirika, gukwirakwira, no gutandukana, biteza imbere kwegeranya kwa matrice idasanzwe, kandi ibintu byinshi bikura biteza imbere gukura kwimisatsi: ibintu bikura muri PRP bikorana numusatsi.Gukomatanya ingirabuzimafatizo zikomeye zitera ubwinshi bwimisatsi, bikabyara ibice, kandi bigatera umusatsi.Mubyongeyeho, irashobora gukora reaction ya cascade yamanuka kandi igatera angiogenez.
Imiterere yubu ya PRP mukuvura AGA
Haracyari ubwumvikane kuburyo bwo gutegura no gutunganya platel ya PRP;uburyo bwo kuvura buratandukanye mumibare yubuvuzi, igihe cyigihe, igihe cyumwiherero, uburyo bwo gutera inshinge, ndetse nimiti ikoreshwa.
Mapar n'abandi.harimo abarwayi 17 b'igitsina gabo bafite icyiciro cya IV kugeza ku cya VI (uburyo bwo kubika Hamilton-Norwood), kandi ibisubizo byagaragaje ko nta tandukaniro riri hagati yo guterwa PRP na placebo, ariko ubushakashatsi bwakozwe gusa inshinge 2, kandi umubare w'ubuvuzi wari muto cyane.Ibisubizo birakinguye kubibazo.;
Gkini n'abandi basanze abarwayi bafite icyiciro cyo hasi bagaragaje ko bitabira cyane kuvura PRP;iki gitekerezo cyemejwe na Qu et al, yarimo abarwayi 51 b'igitsina gabo na 42 b'abagore bafite icyiciro cya II-V ku bagabo na I mu bagore ~ Icyiciro cya III (ikinamico ni uburyo bwo gutegura Hamilton-Norwood na Ludwig), ibisubizo byerekana ko kuvura PRP bifite itandukaniro rinini cyane mubarwayi bafite ibyiciro bitandukanye byabagabo nabagore, ariko ingaruka zicyiciro cyo hasi nicyiciro cyo hejuru nibyiza, abashakashatsi rero basaba ko abarwayi babagabo II, Icyiciro cya III nabarwayi bicyiciro cya mbere bavuwe na PRP.
Ikintu Cyiza Cyuzuye
Itandukaniro muburyo bwo gutegura PRP muri buri nyigo ryatumye habaho gukungahaza kwa PRP muri buri nyigo, inyinshi muri zo zikaba zaribanze hagati yinshuro 2 na 6.Kwangirika kwa platel kurekura umubare munini wibintu bikura, bikagenga kwimuka kwingirabuzimafatizo, kwizirika, gukwirakwizwa no gutandukana, bigatera imisemburo yimisatsi ikwirakwira, imitsi yimitsi, kandi bigatera kwirundanya kwa matrise idasanzwe.Muri icyo gihe, uburyo bwo kuvura microneedling hamwe n’ingufu nkeya za lazeri zifatwa nkibyakozwe na Produces igenzurwa no kwangirika kwinyama kandi bigatera inzira yo kwangirika kwa platine, bigena ubwiza bwibicuruzwa bya PRP biterwa nibikorwa byibinyabuzima.Kubwibyo, ni ngombwa gushakisha uburyo bwiza bwa PRP.Ubushakashatsi bumwe buvuga ko PRP hamwe nubutunzi bwikubye inshuro 1-3 ikora neza kuruta inshuro nyinshi yo gukungahaza, ariko Ayatollahi nibindi.yakoresheje PRP hamwe nubutunzi bwikubye inshuro 1,6 kugirango avurwe, kandi ibisubizo byerekanaga ko kuvura abarwayi ba AGA ntacyo byatwaye, kandi bizeraga ko PRP Kwibanda neza bigomba kuba inshuro 4 ~ 7.
Umubare wubuvuzi, Igihe cyigihe nigihe cyo gusubira inyuma
Ubushakashatsi bwa Mapar n'abandi.na Puig n'abandi.byombi byabonye ibisubizo bibi.Umubare wubuvuzi bwa PRP muri izi protocole zombi zo kwiga wari inshuro 1 na 2, zikaba zari munsi yizindi nyigo (cyane cyane inshuro 3-6).Picard n'abandi.basanze umusaruro wa PRP wageze ku rwego rwo hejuru nyuma yo kuvurwa 3 kugeza kuri 5, bityo bemeza ko hashobora gukenerwa imiti irenga 3 kugira ngo ibimenyetso by’imisatsi bigabanuke.
Isesengura rya Gupta na Carviel ryerekanye ko ubushakashatsi bwinshi bwariho bwari bufite igihe cyo kuvura ukwezi 1, kandi kubera umubare muto w’ubushakashatsi, ibisubizo byo kuvura hakoreshejwe inshinge za PRP buri kwezi ntibyagereranijwe n’izindi nshuro zatewe inshinge, nko gutera PRP buri cyumweru.
Ubushakashatsi bwakozwe na Hausauer na Jones [20] bwerekanye ko amasomo yahawe inshinge buri kwezi yagize iterambere ryinshi mu kubara umusatsi ugereranije ninshuro zatewe inshinge buri mezi 3 (P <0.001);Schiavone n'abandi.[21] yanzuye avuga ko, Ubuvuzi bugomba gusubirwamo nyuma y'amezi 10 kugeza 12 nyuma yo kurangiza amasomo yo kwivuza;Abanyamahanga n'abandi.yakurikiranwe imyaka 2, igihe kirekire cyo gukurikirana mu bushakashatsi bwose, ugasanga abarwayi bamwe basubiye mu mezi 12 (4/20), naho mu barwayi 16 Ibimenyetso bigaragara cyane mu mezi.
Mu gukurikirana Sclafani, byagaragaye ko imikorere y’abarwayi yagabanutse cyane nyuma y’amezi 4 amasomo arangiye.Picard n'abandi.yerekeje ku bisubizo kandi atanga inama zijyanye no kuvura: nyuma yigihe gisanzwe cyo kuvura 3 ukwezi 1, kuvura bigomba gukorwa buri nshuro 3.Kuvura cyane buri kwezi.Icyakora, Sclafani ntabwo yasobanuye igipimo cyo gukungahaza platine y'imyiteguro ikoreshwa mugikorwa cyo kuvura.Muri ubu bushakashatsi, hateguwe ml 8-9 ya fibrin matrix ikungahaye kuri platine kuva miriyoni 18 zamaraso ya periferiya (PRP yakuweho yongewe kumuyoboro wa vacuum wa CaCl2, hanyuma kole ya fibrin ishyirwa muri kole ya fibrin. Gutera mbere yo gushingwa) , twizera ko ububiko bukungahaye kuri platine muriyi myiteguro bushobora kuba kure yihagije, kandi nibindi bimenyetso birakenewe kubishyigikira.
Uburyo bwo gutera inshinge
Benshi muburyo bwo gutera inshinge ni inshinge zo mu nda no gutera inshinge.Abashakashatsi baganiriye ku ngaruka z'uburyo bw'ubuyobozi ku ngaruka zo gukiza.Gupta na Carviel basabye gutera inshinge.Abashakashatsi bamwe bakoresha inshinge zo mu nda.Gutera imbere birashobora gutinza kwinjira kwa PRP mumaraso, kugabanya umuvuduko wa metabolike, kongera igihe cyibikorwa byaho, no kugabanya imbaraga za dermis kugirango imisatsi ikure.kandi ubujyakuzimu ntabwo ari bumwe.Turasaba ko tekinike yo gutera inshinge ya Nappage igomba gukoreshwa cyane mugihe ikora inshinge zo munda kugirango hirindwe ingaruka ziterwa no guterwa inshinge, kandi turasaba ko abarwayi bogosha umusatsi mugufi kugirango barebe icyerekezo cyumusatsi, kandi bahindure inguni yinjizamo inshinge uko bikwiye ukurikije icyerekezo cyo gukura kugirango urushinge rushobore kugera hafi yumusatsi, bityo byongere PRP yibanze mumisatsi.Ibi bitekerezo kuburyo bwo gutera inshinge nibyerekanwe gusa, kuko nta bushakashatsi bugereranya neza ibyiza nibibi byuburyo butandukanye bwo gutera inshinge.
Ubuvuzi
Jha n'abandi.yakoresheje PRP ihujwe na microneedling na 5% minoxidil ikomatanya kuvura kugirango yerekane umusaruro mwiza haba mubimenyetso bifatika no kwisuzumisha abarwayi.Turacyafite imbogamizi muburyo bwo kuvura PRP.Nubwo ubushakashatsi bwinshi bukoresha uburyo bwujuje ubuziranenge no kubara kugirango hamenyekane iterambere ryibimenyetso nyuma yo kuvurwa, nko kubara umusatsi wanyuma, kubara umusatsi wa vellus, kubara umusatsi, ubwinshi, ubunini, nibindi, uburyo bwo gusuzuma buratandukanye cyane;mubyongeyeho, gutegura PRP Nta bipimo bihari muburyo bwuburyo, wongeyeho activateur, centrifugation igihe n'umuvuduko, kwibanda kuri platelet, nibindi.;uburyo bwo kuvura buratandukanye mumibare yubuvuzi, igihe cyigihe, igihe cyumwiherero, uburyo bwo gutera inshinge, no kumenya guhuza imiti;gutoranya ingero mubushakashatsi ntabwo ari Stratification ukurikije imyaka, igitsina, na dogere ya alopecia byarushijeho guhungabanya isuzuma ryingaruka zo kuvura PRP.Mu bihe biri imbere, haracyakenewe ubushakashatsi bunini cyane bwo kwiyobora kugira ngo hasobanurwe ibipimo bitandukanye byo kuvura, kandi hasesengurwe mu buryo butandukanye ibintu nk'imyaka y'abarwayi, igitsina, ndetse n'urwego rwo guta umusatsi birashobora kunozwa buhoro buhoro.
Ibiri muri iyi ngingo byongeye gusubirwamo, kandi ntidutanga ingwate iyo ari yo yose cyangwa yerekana ko ari ukuri, kwiringirwa cyangwa kuzuza ibikubiye muri iyi ngingo, kandi ntabwo dushinzwe ibitekerezo by'iyi ngingo, nyamuneka ubyumve.）
Igihe cyo kohereza: Kanama-02-2022