Platelets, nkibice bigize selile biva mumagufa ya megakaryocytes, birangwa no kubura nuclei.Buri platine irimo ubwoko butatu bwibice, aribyo α Granules, imibiri yuzuye na lysosomes hamwe nubwinshi butandukanye.Muriyo , angiogenezi hamwe nubudahangarwa bwo kurwanya indwara.
Umubiri wuzuye urimo intungamubiri nyinshi za adenosine diphosphate (ADP), adenosine triphosphate (ATP), Ca2 +, Mg2 + na 5-hydroxytryptamine.Lysosomes irimo poroteyine zitandukanye z'isukari, nka glycosidase, protease, proteyine cationic na proteyine zifite ibikorwa bya bagiteri.Izi GF zirekurwa mumaraso nyuma yo gukora platelet.
GF itera cascade reaction muguhuza ubwoko butandukanye bwimikorere ya selile, kandi igakora imirimo yihariye mugikorwa cyo kuvugurura ingirangingo.Kugeza ubu, GF yizwe cyane ni platelet ikomoka kumikurire (PDGF) no guhindura ibintu bikura (TGF- β （TGF- β） factor Imikurire yimitsi iva mu mitsi (VEGF), icyorezo cya epidermal (EGF), gukura kwa fibroblast (FGF), Iterambere ryimyanya myororokere (CTGF) hamwe na insuline imeze nkikura-1 (IGF-1 ).Iyi GF ifasha gusana imitsi, imitsi, ligament nizindi ngingo mugutezimbere ikwirakwizwa ryimikorere no gutandukana, angiogenezi nibindi bikorwa, hanyuma bigakina bihuye uruhare.
Gukoresha PRP muri Vitiligo
Vitiligo, nk'indwara ikunze kwibasira autoimmune, kimwe n'indwara y'uruhu yangirika, igira ingaruka mbi kuri psychologiya y'abarwayi kandi ikagira ingaruka zikomeye ku mibereho y'abarwayi.Muri make, kuba vitiligo ibaho ni ibisubizo byimikoranire yimiterere yimiterere yibidukikije hamwe nibidukikije, bigatuma melanocytes yuruhu yibasirwa kandi ikangirika na sisitemu ya autoimmune.Kugeza ubu, nubwo hari uburyo bwinshi bwo kuvura vitiligo, imikorere yabyo akenshi iba mibi, kandi imiti myinshi ibura ibimenyetso byubuvuzi bushingiye ku bimenyetso.Mu myaka yashize, hamwe nubushakashatsi bukomeje bwo gutera indwara ya vitiligo, uburyo bushya bwo kuvura bwakoreshejwe buri gihe.Nuburyo bwiza bwo kuvura vitiligo, PRP yagiye ikoreshwa.
Kugeza ubu, lazeri 308 nm ya laser na 311 nm nini ya ultraviolet (NB-UVB) hamwe nubundi buryo bwa tekinoroji yo gufotora biramenyekana cyane kubera imikorere yabarwayi bafite vitiligo.Kugeza ubu, gukoresha imiti ya PRP yo mu bwoko bwa microneedle yatewe no gufotora hamwe n’abarwayi bafite vitiligo ihamye byateye imbere cyane.Abdelghani n'abandi.basanze mubushakashatsi bwabo ko PRP autologique PRP subcutaneous microneedle inshinge hamwe na NB-UVB Phototherapy irashobora kugabanya cyane igihe cyose cyo kuvura abarwayi ba vitiligo.
Khattab n'abandi.yavuye abarwayi bafite vitiligo itajegajega hamwe na 308 nm excimer laser na PRP, kandi bageze kubisubizo byiza.Byagaragaye ko guhuza byombi bishobora kuzamura neza igipimo cya lucoplakia, kugabanya igihe cyo kuvura, no kwirinda ingaruka mbi zo gukoresha igihe kirekire gukoresha 308 nm excimer laser irrasiyo.Ubu bushakashatsi bwerekana ko PRP ihujwe no gufotora ari uburyo bwiza bwo kuvura vitiligo.
Ariko, Ibrahim nubundi bushakashatsi burerekana kandi ko PRP yonyine idakora neza mukuvura vitiligo.Kadry n'abandi.yakoze ubushakashatsi buteganijwe ku bijyanye no kuvura vitiligo hamwe na PRP ihujwe na karuboni ya dioxyde de dot matrix laser, isanga PRP ihujwe na karuboni ya dioxyde dot matrix laser na PRP yonyine byageze ku ngaruka nziza yo kubyara amabara.Muri byo, PRP ihujwe na karuboni ya dioxyde de dot matrix laser yagize ingaruka nziza yo kororoka kwamabara, kandi PRP yonyine yari imaze kugera kumyororokere iringaniye muri leukoplakia.Ingaruka yimyororokere yamabara ya PRP yonyine yari nziza kuruta iyo karuboni ya dioxyde dot matrix laser yonyine mukuvura vitiligo.
Igikorwa cyahujwe na PRP mu kuvura Vitiligo
Vitiligo ni ubwoko bw'indwara ya pigment irangwa no kwiheba.Uburyo busanzwe bwo kuvura burimo kuvura imiti, gufotora cyangwa kubaga, cyangwa guhuza uburyo bwinshi bwo kuvura.Ku barwayi bafite vitiligo ihamye kandi idafite ingaruka mbi zo kuvurwa bisanzwe, kuvura kubaga birashobora kuba ubufasha bwa mbere.
Garg n'abandi.yakoresheje PRP nk'umukozi uhagarika ingirabuzimafatizo, kandi yakoresheje Er: YAG laser yo gusya ibibara byera, ibyo bikaba byaragize ingaruka nziza zo kuvura abarwayi ba vitiligo ihamye.Muri ubu bushakashatsi, abarwayi 10 barwaye vitiligo ihamye biyandikishije kandi habonetse ibikomere 20.Mu bisebe 20, ibikomere 12 (60%) byerekanaga ko byakize neza, ibisebe 2 (10%) byagaragaje gukira kwinshi kwa pigment, ibikomere 4 (20%) byagaragaje gukira kwa pigment mu rugero, naho ibikomere 2 (10%) byagaragaje ko nta terambere ryagaragaye.Kugarura amaguru, ingingo zivi, isura nijosi biragaragara cyane, mugihe gukira kwinyuma ari bibi.
Nimitha n'abandi.yakoresheje PRP ihagarika selile epidermal kugirango itegure ihagarikwa na fosiferi ya buffer ihagarika ingirabuzimafatizo kugirango igereranye kandi urebe uko imikurire yabo yibasira abarwayi bafite vitiligo ihamye.Harimo abarwayi ba vitiligo 21 bahamye kandi habonetse ibibara byera 42.Impuzandengo yigihe gihamye cya vitiligo yari imyaka 4.5.Abarwayi benshi berekanye uruziga ruto kugeza kuri oval discret pigment gukira nyuma y'amezi 1-3 nyuma yo kuvurwa.Mugihe cyamezi 6 yo gukurikirana, kugarura pigment byari 75,6% mumatsinda ya PRP na 65% mumatsinda atari PRP.Itandukaniro ryahantu hagarurwa pigment hagati yitsinda rya PRP nitsinda ritari PRP ryari rifite imibare ikomeye.Itsinda rya PRP ryerekanye neza kugarura pigment.Iyo usesenguye igipimo cyo gukira kwa pigment ku barwayi bafite vitiligo igice, nta tandukaniro rikomeye ryari hagati yitsinda rya PRP nitsinda ritari PRP.
Gukoresha PRP muri Chloasma
Melasma ni ubwoko bw'indwara y'uruhu yanduye mu maso, igaragara cyane mu maso y'abagore bakunze guhura n’umucyo ultraviolet kandi bafite ibara ryuruhu rwimbitse.Indwara yacyo ntabwo yasobanuwe neza, kandi biragoye kuvura kandi byoroshye kubisubiramo.Kugeza ubu, kuvura chloasma ahanini bifata uburyo bwo kuvura hamwe.Nubwo inshinge zo munsi ya PRP zifite uburyo butandukanye bwo kuvura chloasma, imikorere yabarwayi ntabwo ishimishije cyane, kandi biroroshye gusubira inyuma nyuma yo guhagarika imiti.Imiti yo mu kanwa nka acide tranexamic na glutathione irashobora gutera uburibwe bwo munda, indwara yimihango, kubabara umutwe, ndetse no gushiraho imitsi yimbitse.
Gushakisha uburyo bushya bwo kuvura chloasma nicyerekezo cyingenzi mubushakashatsi bwa chloasma.Biravugwa ko PRP ishobora guteza imbere cyane ibikomere byuruhu rwabarwayi barwaye melasma.Cay ı rl ı Ibindi.yatangaje ko umukobwa wimyaka 27 yakira inshinge za microneedle ziterwa na PRP buri minsi 15.Nyuma yo kuvura kwa gatatu kwa PRP, byagaragaye ko agace ko gukira indwara ya epidermal pigment yari> 80%, kandi ntagishobora kubaho mu mezi 6.Sirithanabadeekul n'abandi.yakoresheje PRP mu kuvura chloasma kugirango ikore RCT ikaze, ibyo bikaba byemeje kandi akamaro ko gutera inshinge PRP itavura imiti yo kuvura chloasma.
Hofny n'abandi.yakoresheje uburyo bwa immunohistochemicike bwo kuyobora TGF binyuze mu gutera inshinge za microneedle ziterwa na PRP mu gukomeretsa uruhu rw’abarwayi bafite chloasma n’ibice bisanzwe- β Kugereranya imvugo ya poroteyine byagaragaje ko mbere yo kuvura PRP, ibikomere by’uruhu by’abarwayi bafite chloasma na TGF bikikije uruhu- Expression Imvugo ya poroteyine yari hasi cyane ugereranije n’uruhu rwiza (P <0.05).Nyuma yo kuvura PRP, TGF yanduye uruhu kubarwayi barwaye chloasma- expression Imvugo ya poroteyine yariyongereye cyane.Iyi phenomenon yerekana ko ingaruka nziza za PRP kubarwayi ba chloasma zishobora kugerwaho hongerwa TGF yindwara zuruhu- expression Imvugo ya poroteyine igera ku ngaruka zo kuvura chloasma.
Ikoranabuhanga rya Photoelectric rifatanije no gutera inshinge za PRP zo kuvura Chloasma
Hamwe niterambere ryiterambere rya tekinoroji y’amashanyarazi, uruhare rwayo mu kuvura chloasma rwashimishije cyane abashakashatsi.Kugeza ubu, lazeri zikoreshwa mu kuvura chloasma zirimo Q-yahinduwe lazeri, lazeri ya lattice, urumuri rwinshi rwinshi, cuprous bromide laser nizindi ngamba zo kuvura.Ihame ni uko iturika ryatoranijwe rikorwa mubice bya melanin imbere cyangwa hagati ya melanocytes binyuze mu guhitamo ingufu, kandi imikorere ya melanocytes idakora cyangwa ikabuzwa binyuze mu mbaraga nke no guturika kwinshi, kandi icyarimwe, guturika kwinshi kwinshi kwa melanin ikorwa, Irashobora gutuma uduce twa melanin duto kandi tugafasha kumirwa no gusohora umubiri.
Su Bifeng n'abandi.kuvura chloasma hamwe na PRP yatewe urumuri rwamazi hamwe na Q yahinduye Nd: YAG 1064nm laser.Mu barwayi 100 barwaye chloasma, abarwayi 15 bo mu itsinda rya PRP + laser bakize ahanini, abarwayi 22 barateye imbere ku buryo bugaragara, abarwayi 11 barateye imbere, naho umurwayi 1 ntiyagira icyo akora;Mu itsinda rya laser ryonyine, imanza 8 zarakize ahanini, imanza 21 zaragaragaye neza, imanza 18 zaratejwe imbere, naho imanza 3 ntizihinduka.Itandukaniro riri hagati yaya matsinda yombi ryari rifite imibare (P <0.05).Peng Guokai na Song Jiquan barushijeho kugenzura imikorere ya Q-yahinduwe na laser hamwe na PRP mukuvura chloasma yo mumaso.Ibisubizo byerekanaga ko Q-yahinduwe laser ihujwe na PRP yagize akamaro mukuvura chloasma yo mumaso
Nk’ubushakashatsi buriho kuri PRP muri dermatose ya pigment, uburyo bushoboka bwa PRP mukuvura chloasma nuko PRP yongerera TGF ibikomere byuruhu- expression Imvugo ya poroteyine irashobora guteza imbere abarwayi ba melasma.Gutezimbere kwa PRP kuburwayi bwuruhu rwa abarwayi ba vitiligo birashobora kuba bifitanye isano na molekile ya α Adhesion isohorwa na granules ifitanye isano no kuzamura ibidukikije byaho byangiza vitiligo na cytokine.Intangiriro ya vitiligo ifitanye isano rya bugufi nubudahangarwa budasanzwe bwindwara zuruhu.Ubushakashatsi bwerekanye ko ubudahangarwa bw'umubiri bw’abarwayi ba vitiligo bufitanye isano no kunanirwa kwa keratinocytes na melanocytes mu gukomeretsa uruhu kugira ngo birinde kwangirika kwa melanocytes iterwa n’impamvu zitandukanye zitera umuriro na chemokine zasohotse mu gihe cyo guhangayika kwa okiside yo mu nda.Nyamara, ibintu bitandukanye byo gukura kwa platine byasohowe na PRP hamwe na cytokine zitandukanye zirwanya inflammatory zasohowe na platine, nka reseptor ya tumoru necrosis reseptor I, IL-4 na IL-10, zirwanya reseptor ya interleukin-1, zishobora gira uruhare runini muguhuza ubudahangarwa bw'umubiri waho zanduye.
Ibiri muri iyi ngingo byongeye gusubirwamo, kandi ntidutanga ingwate iyo ari yo yose cyangwa yerekana ko ari ukuri, kwiringirwa cyangwa kuzuza ibikubiye muri iyi ngingo, kandi ntabwo dushinzwe ibitekerezo by'iyi ngingo, nyamuneka ubyumve.）
Igihe cyo kohereza: Ugushyingo-24-2022