Gukoresha Clinical nubushakashatsi bwa PRP Indwara Zisanzwe Zivi

Gukoresha ivuriro nubushakashatsi bwa PRP mu ndwara zisanzwe zifata ivi

Plasma ikungahaye kuri platel (PRP) ni plasma igizwe ahanini na platine na selile yamaraso yabonetse hakoreshejwe centrifugation yamaraso ya autologique peripheral.Umubare munini wibintu bikura hamwe na cytokine bibikwa muri α granules ya platine.Iyo platine ikora, α granules yabo irekura umubare munini wibintu bikura.Ubushakashatsi bwerekanye ko ibyo bintu bikura byingirabuzimafatizo bishobora guteza imbere gutandukanya ingirabuzimafatizo, gukwirakwizwa, matrice idasanzwe ndetse na synthesis ya kolagen, bityo bigateza imbere kuvugurura no gusana karitsiye ya artile na ligament naikindiimyenda.Muri icyo gihe, irashobora kandi kunoza uburyo bwo gutwika urubuga rwa lesion no kugabanya ibimenyetso byindwara byabarwayi.Usibye ibyo bintu bikura bikura, PRP irimo kandi umubare munini wamaraso yera.Uturemangingo twamaraso yera na platine birashobora kurekura peptide zitandukanye za mikorobe kugirango zihuze na virusi, zibuza kandi zica virusi, kandi zigira uruhare muri antibacterial.

PRP yakoreshejwe cyane mubijyanye nubuvuzi bwamagufwa bitewe nuburyo bworoshye bwo gukora, gukoresha byoroshye nigiciro gito, cyane cyane mukuvura indwara zivi mumyaka yashize.Iyi ngingo izaganira ku mikorere y’ubuvuzi n’ubushakashatsi bwakozwe na plasma ikungahaye kuri platel mu mavi osteoarthritis (KOA), gukomeretsa kwa menisque, gukomeretsa kw'imitsi, synovitis yo mu ivi n'izindi ndwara zisanzwe zivi.

Ikoreshwa rya tekinoroji ya PRP

PRP idakorewe hamwe na PRP irekuwe irarekuwe kandi irashobora guterwa inshinge, kandi PRP idakorewe irashobora kugenzurwa no kongeramo ibihimbano bya calcium chloride cyangwa trombine kugirango igenzure igihe cya agglutination kugirango gele ikorwe nyuma yo kugera kumwanya wabigenewe, kugirango kugera ku ntego yo kurekura kurambye ibintu bikura.

PRP kuvura KOA

KOA ni indwara yivi yangirika irangwa no gusenya buhoro buhoro karitsiye.Abenshi mu barwayi ni abageze mu zabukuru ndetse n'abasaza.Kugaragara kwa KOA ni kubabara ivi, kubyimba, no kugabanya ibikorwa.Ubusumbane hagati ya synthesis no kubora kwa articular artilage matrix ni ishingiro ryibibaho bya KOA.Kubwibyo, guteza imbere gusana karitsiye no kugenzura uburinganire bwa matrix ya karitsiye nurufunguzo rwo kuyivura.

Kugeza ubu, abarwayi benshi ba KOA bakwiriye kuvurwa neza.Gutera ivi hamwe na aside ya hyaluronike, glucocorticoide nindi miti hamwe n’imiti itari steroid anti-inflammatory imiti ikoreshwa muburyo bwo kuvura indwara.Hamwe n’ubushakashatsi bwimbitse kuri PRP n’intiti zo mu gihugu n’amahanga, kuvura KOA hamwe na PRP byabaye byinshi cyane mu myaka yashize.

Uburyo bwibikorwa:

1. Guteza imbere ikwirakwizwa rya chondrocytes:

Mugupima ingaruka za PRP kubuzima bwa chondrocytes yinkwavu, Wu J nabandi.yasanze PRP yazamuye ikwirakwizwa rya chondrocytes, ikeka ko PRP ishobora kurinda chondrocytes IL-1β ikora ibuza kwanduza ibimenyetso bya Wnt / β-catenin.

2. Kubuza chondrocyte inflammatory reaction no kwangirika:

Iyo ikora, PRP irekura umubare munini wibintu birwanya inflammatory, nka IL-1RA, TNF-Rⅰ, ⅱ, nibindi. Il-1ra irashobora guhagarika ibikorwa bya IL-1 muguhagarika reseptor ya IL-1, na TNF-Rⅰ na ⅱ irashobora guhagarika TNF-α inzira yerekana ibimenyetso.

Kwiga neza:

Ikigaragara nyamukuru ni ukuruhura ububabare no kunoza imikorere yivi.

Lin KY n'abandi.ugereranije inshinge zo mu bwoko bwa LP-PRP na aside hyaluronic na saline isanzwe, ugasanga ingaruka zo gukiza amatsinda abiri yambere zari nziza kuruta iz'itsinda risanzwe rya saline mugihe gito, ryemeje ingaruka zubuvuzi bwa LP-PRP na aside hyaluronike, hamwe no kureba igihe kirekire (nyuma yumwaka 1) byerekanaga ko ingaruka za LP-PRP zari nziza.Ubushakashatsi bumwe bwahujije PRP na aside ya hyaluronike, isanga guhuza PRP na aside hyaluronike bidashobora kugabanya ububabare no kunoza imikorere, ariko kandi byemeza ko X-ray yongeye kuvuka.

Ariko, Filardo G n'abandi.yizeraga ko itsinda rya PRP hamwe na sodium hyaluronate bagize uruhare runini mugutezimbere imikorere yivi nibimenyetso binyuze mubushakashatsi bwateganijwe, ariko nta tandukaniro rikomeye ryabonetse.Byagaragaye ko inzira y'ubuyobozi bwa PRP yagize ingaruka runaka ku ngaruka zo kuvura KOA.Du W n'abandi.yavuzaga KOA akoresheje inshinge za PRP intravarticular no guterwa inshinge zidasanzwe, akareba amanota ya VAS na Lysholm mbere yo gufata imiti n'amezi 1 na 6 nyuma yo gufata imiti.Basanze uburyo bwombi bwo gutera inshinge bushobora kuzamura amanota ya VAS na Lysholm mugihe gito, ariko ingaruka zitsinda ryatewe imbere-arctular zari nziza kuruta itsinda ryatewe inshinge nyuma y amezi 6.Taniguchi Y n'abandi.yagabanije ubushakashatsi ku buvuzi bwa KOA butagereranywa kandi bukabije mu gutera inshinge zifatanije no gutera inshinge zo mu itsinda rya PRP, gutera inshinge zo mu itsinda rya PRP no gutera inshinge zo mu itsinda rya HA.Ubushakashatsi bwerekanye ko guhuza inshinge zo mu nda za PRP no gutera inshinge PRP byari byiza kuruta gutera inshinge PRP cyangwa HA byibuze amezi 18 mugutezimbere amanota VAS na WOMAC.

Ibiri muri iyi ngingo byongeye gusubirwamo, kandi ntidutanga ingwate iyo ari yo yose cyangwa yerekana ko ari ukuri, kwiringirwa cyangwa kuzuza ibikubiye muri iyi ngingo, kandi ntabwo dushinzwe ibitekerezo by'iyi ngingo, nyamuneka ubyumve.）